p(HGNC:PRKN) increases tloc(p(HGNC:SNCAIP, pmod(Ub)), fromLoc(GO:cytosol), toLoc(MESH:"Inclusion Bodies"))

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PubMed:14556719

Since inclusion bodies are lacking in most cases of AR-JP, it is possible that the ubiquitination of Synphilin by wildtype Parkin plays a role in their formation, by targeting ubiquitinated Synphilin to these bodies and removing it from the cytosol where it can be toxic

Related Edges 3

• a(MESH:"Inclusion Bodies") negativeCorrelation path(MESH:"Parkinsonian Disorders")
• p(HGNC:PRKN) increases p(HGNC:SNCAIP, pmod(Ub))
• path(MESH:"Parkinsonian Disorders") negativeCorrelation a(MESH:"Inclusion Bodies")

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