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p(HGNC:PRKCA)

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Entity

Name
PRKCA
Namespace
HGNC
Namespace Version
20180215
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/namespace/hgnc/hgnc-20180215.belns

Appears in Networks 2

APP processing in Alzheimer's disease v1.0.1

APP processing in Alzheimer's disease

Proteolytic processing of Alzeimer's beta-amyloid precursor protein v1.0.1

In-Edges 1

a(CHEBI:"phorbol ester") increases act(p(HGNC:PRKCA)) View Subject | View Object

Indeed, phorbol ester’s effect on sAPPalpha secretion and Abeta generation though activation of protein kinase C (PKC) has been known for a long time [201-203] PubMed:21214928

Appears in Networks:
Annotations
MeSH
Cell Membrane
Confidence
High
MeSH
Hippocampus
MeSH
Down Syndrome

Out-Edges 7

act(p(HGNC:PRKCA)) increases sec(a(HBP:HBP00067)) View Subject | View Object

Interestingly, the stimulation of sAPPalpha secretion by estrogen can be blocked by a PKC inhibitor, suggesting the involvement of a PKC-dependent pathway [200] PubMed:21214928

Appears in Networks:
Annotations
MeSH
Cell Membrane
Confidence
High
MeSH
Hippocampus
MeSH
Down Syndrome

p(HGNC:PRKCA) increases sec(a(HBP:HBP00067)) View Subject | View Object

PKC stimulates sAPPalpha secretion, reducing Abeta levels, even when the phosphorylation sites on APP are mutated or the entire cytoplasmic domain is deleted [204] PubMed:21214928

Appears in Networks:
Annotations
MeSH
Cell Membrane
Confidence
High
MeSH
Hippocampus
MeSH
Down Syndrome

p(HGNC:PRKCA) decreases a(CHEBI:"amyloid-beta") View Subject | View Object

PKC stimulates sAPPalpha secretion, reducing Abeta levels, even when the phosphorylation sites on APP are mutated or the entire cytoplasmic domain is deleted [204] PubMed:21214928

Appears in Networks:
Annotations
MeSH
Cell Membrane
Confidence
High
MeSH
Hippocampus
MeSH
Down Syndrome

p(HGNC:PRKCA) directlyIncreases p(HGNC:APP, pmod(Ph, Ser, 655)) View Subject | View Object

While PKC can directly phosphorylate APP Ser655 [205], it appears to affect APP metabolism by phosphorylating a different target PubMed:21214928

Appears in Networks:
Annotations
MeSH
Cell Membrane
Confidence
High
MeSH
Hippocampus
MeSH
Down Syndrome

p(HGNC:PRKCA) increases p(HBP:HBP00071, pmod(Ph, Thr, 654)) View Subject | View Object

AICD also contains three phosphorylation sites, including two threonine residues at 654 and 668 and a serine residue at 665. AICD has been found to be phosphorylated by PKC, calcium-calmodulin dependent-kinase II, GSK3-b, Cdk5 and c-Jun N-terminal kinase (JNK) at the Ser/Thr sites mentioned above PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

p(HGNC:PRKCA) increases p(HBP:HBP00071, pmod(Ph, Thr, 668)) View Subject | View Object

AICD also contains three phosphorylation sites, including two threonine residues at 654 and 668 and a serine residue at 665. AICD has been found to be phosphorylated by PKC, calcium-calmodulin dependent-kinase II, GSK3-b, Cdk5 and c-Jun N-terminal kinase (JNK) at the Ser/Thr sites mentioned above PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

p(HGNC:PRKCA) increases p(HBP:HBP00071, pmod(Ph, Ser, 665)) View Subject | View Object

AICD also contains three phosphorylation sites, including two threonine residues at 654 and 668 and a serine residue at 665. AICD has been found to be phosphorylated by PKC, calcium-calmodulin dependent-kinase II, GSK3-b, Cdk5 and c-Jun N-terminal kinase (JNK) at the Ser/Thr sites mentioned above PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.