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a(MESH:"Potassium Channels")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Potassium Channels
Namespace
mesh
Namespace Version
20180828
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/mesh-names.belns

Appears in Networks 2

APP processing in Alzheimer's disease v1.0.1

APP processing in Alzheimer's disease

Alzheimer's Disease: Targeting the Cholinergic System v1.0.0

In-Edges 6

a(CHEBI:"amyloid-beta") association a(MESH:"Potassium Channels") View Subject | View Object

Picomolar levels of Abeta can also rescue neuronal cell death induced by inhibition of Abeta generation (by exposure to inhibitors of beta- or gamma-scretases) [160], possibly through regulating the potassium ion channel expression, hence affecting neuronal excitability [161] PubMed:21214928

Appears in Networks:
Annotations
MeSH
Endosomes
Confidence
Low
MeSH
Hippocampus
MeSH
Down Syndrome

p(FPLX:CHRM) regulates act(a(MESH:"Potassium Channels")) View Subject | View Object

As a consequence, stimulation of ACh muscarinic receptors can promote the opening or closing of Ca2+, K+, or Cl- channels, which might facilitate either depolarization or hyperpolarization, depending on the cell type where these receptors are expressed PubMed:26813123

Appears in Networks:

act(p(FPLX:CHRM)) decreases act(a(MESH:"Potassium Channels")) View Subject | View Object

Activation of muscarinic receptors can block various types of K+ currents by inhibiting many resting and voltage-gated K+ channels PubMed:26813123

Appears in Networks:

complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels")) View Subject | View Object

Stimulation of Gαq coupled muscarinic receptors leads to activation of phospholipase C and formation of inositol phosphates and other second messengers, which can promote closure of K+ channels, thus facilitating cell excitability PubMed:26813123

Appears in Networks:

complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels")) View Subject | View Object

Stimulation of Gαq coupled muscarinic receptors leads to activation of phospholipase C and formation of inositol phosphates and other second messengers, which can promote closure of K+ channels, thus facilitating cell excitability PubMed:26813123

Appears in Networks:

complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels")) View Subject | View Object

Stimulation of Gαq coupled muscarinic receptors leads to activation of phospholipase C and formation of inositol phosphates and other second messengers, which can promote closure of K+ channels, thus facilitating cell excitability PubMed:26813123

Appears in Networks:

Out-Edges 1

a(MESH:"Potassium Channels") association a(CHEBI:"amyloid-beta") View Subject | View Object

Picomolar levels of Abeta can also rescue neuronal cell death induced by inhibition of Abeta generation (by exposure to inhibitors of beta- or gamma-scretases) [160], possibly through regulating the potassium ion channel expression, hence affecting neuronal excitability [161] PubMed:21214928

Appears in Networks:
Annotations
MeSH
Endosomes
Confidence
Low
MeSH
Hippocampus
MeSH
Down Syndrome

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.