1. Catalog
  2. Nodes
  3. a(GO:"late endosome")

a(GO:"late endosome")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
late endosome
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 3

Interplay of pathogenic forms of human tau with different autophagic pathways v1.0.1

Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways v1.0.1

The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease v1.0.0

In-Edges 4

a(HBP:"Tau aggregates") association a(GO:"late endosome") View Subject | View Object

Monomeric and aggregated tau-Dylight were also detected in LAMP1+late endosomes and lysosomes, consistent with endocytosed proteins first reaching early endosomes, before late endosomes and lysosomes PubMed:29590627

Appears in Networks:

p(HGNC:MAPT, var("p.Pro301Ser")) association a(GO:"late endosome") View Subject | View Object

Monomeric and aggregated tau-Dylight were also detected in LAMP1+late endosomes and lysosomes, consistent with endocytosed proteins first reaching early endosomes, before late endosomes and lysosomes PubMed:29590627

Appears in Networks:

complex(a(GO:"early endosome"), a(GO:"late endosome")) hasComponent a(GO:"late endosome") View Subject | View Object

Appears in Networks:

complex(a(GO:"late endosome"), a(GO:autophagosome), a(GO:lysosome)) hasComponent a(GO:"late endosome") View Subject | View Object

Appears in Networks:

Out-Edges 5

a(GO:"late endosome") increases deg(p(MGI:Mapt)) View Subject | View Object

We found that WT tau was taken up and efficiently degraded by LE (Fig. 2c,d) PubMed:29024336

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain

a(GO:"late endosome") decreases deg(p(MGI:Mapt, var("p.Pro301Leu"))) View Subject | View Object

This process was significantly impaired for tau-P301L and, to higher extent, for tau- A152T (Fig. 2c,d) PubMed:29024336

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain

a(GO:"late endosome") decreases deg(p(MGI:Mapt, var("p.Ala152Thr"))) View Subject | View Object

This process was significantly impaired for tau-P301L and, to higher extent, for tau- A152T (Fig. 2c,d) PubMed:29024336

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain

a(GO:"late endosome") association p(HGNC:MAPT, var("p.Pro301Ser")) View Subject | View Object

Monomeric and aggregated tau-Dylight were also detected in LAMP1+late endosomes and lysosomes, consistent with endocytosed proteins first reaching early endosomes, before late endosomes and lysosomes PubMed:29590627

Appears in Networks:

a(GO:"late endosome") association a(HBP:"Tau aggregates") View Subject | View Object

Monomeric and aggregated tau-Dylight were also detected in LAMP1+late endosomes and lysosomes, consistent with endocytosed proteins first reaching early endosomes, before late endosomes and lysosomes PubMed:29590627

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.