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p(HGNC:MAPT, frag("?_*"))

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Entity

Name
MAPT
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease v1.0.0

In-Edges 6

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, frag("?_*")) View Subject | View Object

Appears in Networks:

act(p(HGNC:CASP3)) increases p(HGNC:MAPT, frag("?_*")) View Subject | View Object

There is significant evidence that tau is a caspase substrate and that caspase-mediated tau cleavage may play a role in AD pathology. Early in vitro studies demonstrated that tau is cleaved in the C-terminus by several caspases including caspase-3 and caspase-6 (21–23). PubMed:24027553

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act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("?_*")) View Subject | View Object

There is significant evidence that tau is a caspase substrate and that caspase-mediated tau cleavage may play a role in AD pathology. Early in vitro studies demonstrated that tau is cleaved in the C-terminus by several caspases including caspase-3 and caspase-6 (21–23). PubMed:24027553

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act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("?_*")) View Subject | View Object

Furthermore, active caspase co-localizes to NFTs (58), and caspase-cleaved tau is found in AD-affected brain regions, particularly in neurons displaying tangle pathology (59, 60). This includes tau cleaved by caspase-6 in the C-terminus (58–60) as well as in the N-terminus (24). TauC3 is present in AD brain – in neurons and co-localized with NFTs – and inversely correlates with cognitive function (55, 60, 61). PubMed:24027553

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MeSH
Alzheimer Disease
Text Location
Review

p(HGNC:NPEPPS) increases p(HGNC:MAPT, frag("?_*")) View Subject | View Object

PSA was able to cleave recombinant tau in vitro, as well as tau from control human brain (11). However, the data presented in this study suggest that PSA is cleaving tau from both the C- and N-terminal ends, which is not expected from an aminopeptidase. Additionally, other studies failed to demonstrate tau cleavage by PSA (28, 29). PubMed:24027553

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MeSH
Brain
Text Location
Review

path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, frag("?_*")) View Subject | View Object

The predominant post-translational modification of tau in the NFTs is phosphorylation; however numerous modifications have been noted including truncation, acetylation, nitration, and several others (2–4). PubMed:24027553

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Out-Edges 1

p(HGNC:MAPT, frag("?_*")) association path(MESH:"Neurofibrillary Tangles") View Subject | View Object

The predominant post-translational modification of tau in the NFTs is phosphorylation; however numerous modifications have been noted including truncation, acetylation, nitration, and several others (2–4). PubMed:24027553

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Text Location
Review

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.