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p(HGNC:GPR37)

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Entity

Name
GPR37
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg v1.0.0

In-Edges 4

bp(GO:"cell death") positiveCorrelation p(HGNC:GPR37) View Subject | View Object

It then aggregates, and the insoluble protein elicits cell death via the Unfolded Protein Response (UPR). PubMed:14556719

Appears in Networks:

p(HGNC:PRKN) association p(HGNC:GPR37) View Subject | View Object

A second important substrate of Parkin is the Parkin-associated endothelial-like (Pael) receptor, a putative G protein-coupled transmembrane polypeptide (Imai et al., 2001). When overexpressed in cells, the receptor becomes misfolded PubMed:14556719

Appears in Networks:

composite(p(HGNC:PRKN), p(HGNC:UBE2G1), p(HGNC:UBE2J1)) increases deg(p(HGNC:GPR37)) View Subject | View Object

Parkin ubiquitinates and promotes the degradation of the insoluble Pael receptor, acting in this reaction along Ubc6 and Ubc7, two E2s located in the ER PubMed:14556719

Appears in Networks:
Annotations
MeSH
Endoplasmic Reticulum

path(MESH:"Parkinsonian Disorders") positiveCorrelation p(HGNC:GPR37) View Subject | View Object

Importantly, the insoluble Pael receptor accumulates in the brains of patients with AR-JP PubMed:14556719

Appears in Networks:
Annotations
MeSH
Brain

Out-Edges 5

p(HGNC:GPR37) hasVariant p(HGNC:GPR37, pmod(HBP:misfolding)) View Subject | View Object

Appears in Networks:

p(HGNC:GPR37) increases p(HGNC:GPR37, pmod(HBP:misfolding)) View Subject | View Object

A second important substrate of Parkin is the Parkin-associated endothelial-like (Pael) receptor, a putative G protein-coupled transmembrane polypeptide (Imai et al., 2001). When overexpressed in cells, the receptor becomes misfolded PubMed:14556719

Appears in Networks:

p(HGNC:GPR37) association p(HGNC:PRKN) View Subject | View Object

A second important substrate of Parkin is the Parkin-associated endothelial-like (Pael) receptor, a putative G protein-coupled transmembrane polypeptide (Imai et al., 2001). When overexpressed in cells, the receptor becomes misfolded PubMed:14556719

Appears in Networks:

p(HGNC:GPR37) positiveCorrelation bp(GO:"cell death") View Subject | View Object

It then aggregates, and the insoluble protein elicits cell death via the Unfolded Protein Response (UPR). PubMed:14556719

Appears in Networks:

p(HGNC:GPR37) positiveCorrelation path(MESH:"Parkinsonian Disorders") View Subject | View Object

Importantly, the insoluble Pael receptor accumulates in the brains of patients with AR-JP PubMed:14556719

Appears in Networks:
Annotations
MeSH
Brain

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.