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complex(a(GO:lysosome), p(MGI:Mapt))

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Components

Appears in Networks 1

Interplay of pathogenic forms of human tau with different autophagic pathways v1.0.1

In-Edges 2

p(MGI:Mapt, var("p.Pro301Leu")) decreases complex(a(GO:lysosome), p(MGI:Mapt)) View Subject | View Object

In contrast, the P301L mutation severely impaired lysosomal uptake of tau by CMA, resulting in a sixfold decrease in degradation when compared to WT tau protein (Fig. 1c,d) PubMed:29024336

Appears in Networks:
Annotations
MeSH
Lysosomes
Confidence
High
MeSH
Brain

p(MGI:Mapt, var("p.Pro301Leu")) decreases complex(a(GO:lysosome), p(MGI:Mapt)) View Subject | View Object

Reduced tau-P301L uptake is not caused by a problem in translocation across the lysosomal membrane, but rather by reduced targeting/binding to lysosomes, as we did not detect tau accumulation at the lysosomal membrane PubMed:29024336

Appears in Networks:
Annotations
MeSH
Lysosomes
Confidence
Medium
MeSH
Brain

Out-Edges 2

complex(a(GO:lysosome), p(MGI:Mapt)) hasComponent a(GO:lysosome) View Subject | View Object

Appears in Networks:

complex(a(GO:lysosome), p(MGI:Mapt)) hasComponent p(MGI:Mapt) View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.