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a(MESH:"Inclusion Bodies")

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Entity

Name
Inclusion Bodies
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg v1.0.0

In-Edges 7

complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) hasComponent a(MESH:"Inclusion Bodies") View Subject | View Object

Appears in Networks:

complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) hasComponent a(MESH:"Inclusion Bodies") View Subject | View Object

Appears in Networks:

p(HGNC:SNCA) association a(MESH:"Inclusion Bodies") View Subject | View Object

In addition, other proteins, e.g., alphaSYN (Waelter et al., 2001) and the transcriptional cofactor CREB binding protein (CBP) (Jiang et al., 2003),colocalize with the protein inclusions PubMed:14556719

Appears in Networks:

composite(p(HGNC:SNCA), p(HGNC:SNCAIP)) increases a(MESH:"Inclusion Bodies") View Subject | View Object

Overexpression of Synphilin-1 with alphaSYN results in the formation of protein inclusions, yet the function of Synphilin in this process as well as the role of its ubiquitination are still elusive PubMed:14556719

Appears in Networks:

p(HGNC:CDC34, var("?")) decreases a(MESH:"Inclusion Bodies") View Subject | View Object

Tentative support for this idea was obtained in a cell model of HD, where expression of a dominant-negative variant of the E2 Cdc34p decreased the formation of intranuclear inclusions but increased the likelihood of cell death (Saudou et al., 1998). PubMed:14556719

Appears in Networks:
Annotations
MeSH
Huntington Disease

p(HGNC:CREBBP) association a(MESH:"Inclusion Bodies") View Subject | View Object

In addition, other proteins, e.g., alphaSYN (Waelter et al., 2001) and the transcriptional cofactor CREB binding protein (CBP) (Jiang et al., 2003),colocalize with the protein inclusions PubMed:14556719

Appears in Networks:

path(MESH:"Parkinsonian Disorders") negativeCorrelation a(MESH:"Inclusion Bodies") View Subject | View Object

Since inclusion bodies are lacking in most cases of AR-JP, it is possible that the ubiquitination of Synphilin by wildtype Parkin plays a role in their formation, by targeting ubiquitinated Synphilin to these bodies and removing it from the cytosol where it can be toxic PubMed:14556719

Appears in Networks:

Out-Edges 3

a(MESH:"Inclusion Bodies") negativeCorrelation path(MESH:"Parkinsonian Disorders") View Subject | View Object

Since inclusion bodies are lacking in most cases of AR-JP, it is possible that the ubiquitination of Synphilin by wildtype Parkin plays a role in their formation, by targeting ubiquitinated Synphilin to these bodies and removing it from the cytosol where it can be toxic PubMed:14556719

Appears in Networks:

a(MESH:"Inclusion Bodies") association p(HGNC:SNCA) View Subject | View Object

In addition, other proteins, e.g., alphaSYN (Waelter et al., 2001) and the transcriptional cofactor CREB binding protein (CBP) (Jiang et al., 2003),colocalize with the protein inclusions PubMed:14556719

Appears in Networks:

a(MESH:"Inclusion Bodies") association p(HGNC:CREBBP) View Subject | View Object

In addition, other proteins, e.g., alphaSYN (Waelter et al., 2001) and the transcriptional cofactor CREB binding protein (CBP) (Jiang et al., 2003),colocalize with the protein inclusions PubMed:14556719

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.