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bp(GO:"mitochondrion organization")

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Entity

Name
mitochondrion organization
Namespace
go
Namespace Version
20181221
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/73688d6dc24e309fca59a1340dc9ee971e9f3baa/external/go-names.belns

Appears in Networks 1

Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage v1.0.0

Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage from Shafiei et al., 2017

In-Edges 3

a(HBP:"Tau oligomers") decreases bp(GO:"mitochondrion organization") View Subject | View Object

When tau oligomers, rather than tau monomers or fibrils, are injected into the brain of wild-type mice, cognitive, synaptic, and mitochondrial abnormalities follow (Lasagna- Reeves et al., 2011; Castillo-Carranza et al., 2014b) PubMed:28420982

Appears in Networks:
Annotations
Confidence
High
MeSH
Cerebral Cortex

p(HGNC:MAPT, frag("1_421")) decreases bp(GO:"mitochondrion organization") View Subject | View Object

Another study showed that expression of tau (truncated at Asp-421 to mimic caspase cleavage) caused mitochondrial dysfunction (Quintanilla et al., 2009) PubMed:28420982

Appears in Networks:
Annotations
MeSH
Extracellular Space
Confidence
Low
MeSH
Neurons
MeSH
Alzheimer Disease

p(HGNC:MAPT, frag("421_?")) decreases bp(GO:"mitochondrion organization") View Subject | View Object

Another study showed that expression of tau (truncated at Asp-421 to mimic caspase cleavage) caused mitochondrial dysfunction (Quintanilla et al., 2009) PubMed:28420982

Appears in Networks:
Annotations
MeSH
Extracellular Space
Confidence
Low
MeSH
Neurons
MeSH
Alzheimer Disease

Out-Edges 1

bp(GO:"mitochondrion organization") decreases bp(HP:Neurodegeneration) View Subject | View Object

In aging, a protein involved in mitochondrial fission, dynamin-related protein 1 (DRP1), can bind tau abnormally, inducing neurodegeneration via mitochondrial dysfunction (Figure 2; DuBoff et al., 2012) PubMed:28420982

Appears in Networks:
Annotations
MeSH
Extracellular Space
Confidence
Medium
MeSH
Neurons
MeSH
Alzheimer Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.