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a(CHEBI:chlorpromazine)

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Entity

Name
chlorpromazine
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 2

The Nicotinic Acetylcholine Receptor: The Founding Father of the Pentameric Ligand-gated Ion Channel Superfamily v1.0.1

mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders v1.0.0

In-Edges 4

complex(a(CHEBI:chlorpromazine), p(MESH:"Receptors, Nicotinic")) hasComponent a(CHEBI:chlorpromazine) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) association a(CHEBI:chlorpromazine) View Subject | View Object

In receptor-rich mem- branes from T. marmorata, chlorpromazine labeled the four types of subunits of the nAChR (67), and precise quantitative measurements demonstrated that it bound to just one high affinity site per 2alpha􏰀1beta􏰂1gamma􏰃1delta􏰄1 oligomer (68). PubMed:23038257

Appears in Networks:

p(HGNC:ACHE) increases act(a(CHEBI:chlorpromazine)) View Subject | View Object

The kinetics of access of chlorpromazine to this site increased by 100-fold when rap- idly mixed with ACh under conditions expected to generate functional ion channels PubMed:23038257

Appears in Networks:

p(HGNC:SCNN1D) association a(CHEBI:chlorpromazine) View Subject | View Object

It took more than a year to demonstrate that chlorpromazine labels serine 262, within the second transmembrane segment (TM2) of the delta􏰄-subunit PubMed:23038257

Appears in Networks:

Out-Edges 5

a(CHEBI:chlorpromazine) association complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) View Subject | View Object

In receptor-rich mem- branes from T. marmorata, chlorpromazine labeled the four types of subunits of the nAChR (67), and precise quantitative measurements demonstrated that it bound to just one high affinity site per 2alpha􏰀1beta􏰂1gamma􏰃1delta􏰄1 oligomer (68). PubMed:23038257

Appears in Networks:

a(CHEBI:chlorpromazine) association p(HGNC:SCNN1D) View Subject | View Object

It took more than a year to demonstrate that chlorpromazine labels serine 262, within the second transmembrane segment (TM2) of the delta􏰄-subunit PubMed:23038257

Appears in Networks:

a(CHEBI:chlorpromazine) increases bp(GO:autophagy) View Subject | View Object

In contrast, chlorpromazine, which is a typical antipsychotic agent, induces autophagy by inhibiting the Akt/mTOR pathway PubMed:30061532

Appears in Networks:

a(CHEBI:chlorpromazine) decreases bp(GO:"protein kinase B signaling") View Subject | View Object

In contrast, chlorpromazine, which is a typical antipsychotic agent, induces autophagy by inhibiting the Akt/mTOR pathway PubMed:30061532

Appears in Networks:

a(CHEBI:chlorpromazine) decreases act(p(HGNC:MTOR)) View Subject | View Object

In contrast, chlorpromazine, which is a typical antipsychotic agent, induces autophagy by inhibiting the Akt/mTOR pathway PubMed:30061532

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.