1. Catalog
  2. Nodes
  3. path(MESH:"Kidney Diseases")

path(MESH:"Kidney Diseases")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Kidney Diseases
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 2

Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation v1.0.0

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 3

act(p(HGNC:NFE2L2)) negativeCorrelation path(MESH:"Kidney Diseases") View Subject | View Object

The study suggests that Nrf2 activation represents a viable new therapeutic approach for renal disease, as similar results are not achievable with currently available therapies PubMed:22020111

Appears in Networks:

p(HGNC:HBB) positiveCorrelation path(MESH:"Kidney Diseases") View Subject | View Object

Third, exposure to extracellular Hb, in the form of oxygen therapeutics or when Hb is released from old red blood cells, have also been reported to induce oxidative toxicity in kidney and brain tissues [65]. PubMed:24486321

Appears in Networks:
Annotations
Text Location
Discussion

p(HGNC:HPX) decreases path(MESH:"Kidney Diseases") View Subject | View Object

In fact, hemolysis or heme injection in Hx−/− mice cause increased inflammation and severe renal damage compared to wild type (WT) mice (Tolosano et al., 1999; Vinchi et al., 2008). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Review

Out-Edges 2

path(MESH:"Kidney Diseases") negativeCorrelation act(p(HGNC:NFE2L2)) View Subject | View Object

The study suggests that Nrf2 activation represents a viable new therapeutic approach for renal disease, as similar results are not achievable with currently available therapies PubMed:22020111

Appears in Networks:

path(MESH:"Kidney Diseases") positiveCorrelation p(HGNC:HBB) View Subject | View Object

Third, exposure to extracellular Hb, in the form of oxygen therapeutics or when Hb is released from old red blood cells, have also been reported to induce oxidative toxicity in kidney and brain tissues [65]. PubMed:24486321

Appears in Networks:
Annotations
Text Location
Discussion

About

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.