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bp(GO:"long term synaptic depression")

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Entity

Name
long term synaptic depression
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 2

Amyloid β oligomers (AβOs) in Alzheimer’s disease v1.0.0

Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System v1.0.0

In-Edges 2

a(HBP:HBP00074) increases bp(GO:"long term synaptic depression") View Subject | View Object

In normal rats, impaired memory of a learned behavior was observed after intraventricular application of soluble oligomers of Aβ42 isolated directly from human AD brains (Shankar et al. 2008). Furthermore, AβO injections resulted in reduction of a synapse number and their function in dose-dependent manner. It also led to the inhibition of LTP and enhancement of long-term synaptic depression (LTD) in rodent hippocampus (Shankar et al. 2008). PubMed:29196815

Appears in Networks:
Annotations
MeSH
Extracellular Space
Cell Ontology (CL)
neuron
Confidence
High
MeSH
Hippocampus

act(p(FPLX:CHRN)) increases bp(GO:"long term synaptic depression") View Subject | View Object

Activation and desensitization of nAChRs by bath-applied nicotine also increases LTD induced by a stimulus train PubMed:17009926

Appears in Networks:

Out-Edges 0

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.