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  3. complex(a(MESH:"Dihydro-beta-Erythroidine"), a(MESH:"nicotinic receptor alpha4beta2"))

complex(a(MESH:"Dihydro-beta-Erythroidine"), a(MESH:"nicotinic receptor alpha4beta2"))

Appears in Networks 1

Discriminative Stimulus Properties of S(−)-Nicotine: “A Drug for All Seasons v1.0.0

In-Edges 1

a(MESH:"Dihydro-beta-Erythroidine") increases complex(a(MESH:"Dihydro-beta-Erythroidine"), a(MESH:"nicotinic receptor alpha4beta2")) View Subject | View Object

This conclusion is based on the fact that the stimulus effects of nicotine are convincingly blocked by (a) mecamylamine, a voltage dependent noncompetitive channel blocker at nicotinic receptors (Fig. 3; Table 4) and (b) dihydro-β-erythrodine (DHβE), a nicotinic receptor antagonist that shows high affinity for the nAChR α4β2 subunit (Fig. 3; Table 5) but not by methyllycaconitine (MLA), a α7 nicotinic receptor antagonist (Table 5). PubMed:28391535

Appears in Networks:

Out-Edges 2

complex(a(MESH:"Dihydro-beta-Erythroidine"), a(MESH:"nicotinic receptor alpha4beta2")) hasComponent a(MESH:"Dihydro-beta-Erythroidine") View Subject | View Object

Appears in Networks:

complex(a(MESH:"Dihydro-beta-Erythroidine"), a(MESH:"nicotinic receptor alpha4beta2")) hasComponent a(MESH:"nicotinic receptor alpha4beta2") View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.