The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.
|BEL Framework Large Corpus Document v20170611||88%|
|Selventa Protein Families Definitions v20150611||67%|
|Jak Stat-2.0-Hs v2.0||55%|
|Jak Stat-2.0-Mm v2.0||48%|
|BEL Framework Small Corpus Document v20150611||29%|
|Megakaryocyte Differentiation-2.0-Rn v2.0||29%|
|Growth Factor-2.0-Rn v2.0||27%|
|Wound Healing-2.0-Rn v2.0||25%|
|Colorectal Cancer Model v2.0.6||23%|
|Oxidative Stress-2.0-Rn v2.0||21%|
NRG-1 induces cell proliferation through a high-affinity receptor complex composed of a heterodimer of human epidermal growth factor-like receptor (HER) 2 and 3. In this study, we show that NRG-1 activates the Janus kinases (JAK) and signal transducer and activator of transcription proteins (STAT). NRG-1 induced a rapid and transient increase in tyrosine phosphorylation of TYK2 and JAK3, but not JAK1 or JAK2, and induced STAT3 and STAT5 tyrosine phosphorylation
The signaling pathway of type I IFNs activates STAT1 and STAT2. In primary endothelial cells, we demonstrate that STAT3 and STAT5 are also activated, and these STATs may contribute to cellular proliferation
PhosphoElm data from PMID 15212693
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