Provenance

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charles.hoyt@scai.fraunhofer.de at 2018-04-03 15:16:59
Authors
Causal Biological Networks Database
Contact
CausalBiologicalNetworks.RD@pmi.com
Description
The Jak Stat network depicts the causal mechanisms involved in canonical Jak Stat signaling leading to cell proliferation and components of cell cycle machinery (e.g. cyclins, CDKN1B).
License
Please cite: - www.causalbionet.com - https://bionet.sbvimprover.com as well as any relevant publications. The sbv IMPROVER project, the website and the Symposia are part of a collaborative project designed to enable scientists to learn about and contribute to the development of a new crowd sourcing method for verification of scientific data and results. The current challenges, website and biological network models were developed and are maintained as part of a collaboration among Selventa, OrangeBus and ADS. The project is led and funded by Philip Morris International. For more information on the focus of Philip Morris International’s research, please visit www.pmi.com.
Number Nodes
48
Number Edges
144
Number Components
6
Network Density
0.0638298
Average Degree
3.0
Number Citations
95
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
BEL Framework Large Corpus Document v20170611 88%
Selventa Protein Families Definitions v20150611 67%
Jak Stat-2.0-Hs v2.0 55%
Jak Stat-2.0-Mm v2.0 48%
BEL Framework Small Corpus Document v20150611 29%
Megakaryocyte Differentiation-2.0-Rn v2.0 29%
Growth Factor-2.0-Rn v2.0 27%
Wound Healing-2.0-Rn v2.0 25%
Colorectal Cancer Model v2.0.6 23%
Oxidative Stress-2.0-Rn v2.0 21%

Sample Edges

act(p(SFAM:"STAT5 Family"), ma(tscript)) increases bp(GOBP:"cell proliferation")

NRG-1 induces cell proliferation through a high-affinity receptor complex composed of a heterodimer of human epidermal growth factor-like receptor (HER) 2 and 3. In this study, we show that NRG-1 activates the Janus kinases (JAK) and signal transducer and activator of transcription proteins (STAT). NRG-1 induced a rapid and transient increase in tyrosine phosphorylation of TYK2 and JAK3, but not JAK1 or JAK2, and induced STAT3 and STAT5 tyrosine phosphorylation PubMed:12204892

act(p(SFAM:"STAT5 Family"), ma(tscript)) increases bp(GOBP:"cell proliferation")

The signaling pathway of type I IFNs activates STAT1 and STAT2. In primary endothelial cells, we demonstrate that STAT3 and STAT5 are also activated, and these STATs may contribute to cellular proliferation PubMed:12759411

Sample Nodes

p(RGD:Mapk3)

In-Edges: 173 | Out-Edges: 60 | Explore Neighborhood | Download JSON

p(SFAM:"STAT5 Family")

In-Edges: 123 | Out-Edges: 61 | Explore Neighborhood | Download JSON

p(HGNC:STAT3)

In-Edges: 441 | Out-Edges: 466 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of the open source project, PyBEL. Please feel free to contact us here to give us feedback or report any issues.