Upload at 2018-04-03 15:16:59
Causal Biological Networks Database
The Jak Stat network depicts the causal mechanisms involved in canonical Jak Stat signaling leading to cell proliferation and components of cell cycle machinery (e.g. cyclins, CDKN1B).
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Number Nodes
Number Edges
Number Components
Network Density
Average Degree
Number Citations
Number BEL Errors

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
BEL Framework Large Corpus Document v20170611 88%
Selventa Protein Families Definitions v20150611 67%
Jak Stat-2.0-Hs v2.0 55%
Jak Stat-2.0-Mm v2.0 48%
BEL Framework Small Corpus Document v20150611 29%
Megakaryocyte Differentiation-2.0-Rn v2.0 29%
Growth Factor-2.0-Rn v2.0 27%
Wound Healing-2.0-Rn v2.0 25%
Colorectal Cancer Model v2.0.6 23%
Oxidative Stress-2.0-Rn v2.0 21%

Sample Edges

act(p(SFAM:"STAT5 Family"), ma(tscript)) increases bp(GOBP:"cell proliferation")

NRG-1 induces cell proliferation through a high-affinity receptor complex composed of a heterodimer of human epidermal growth factor-like receptor (HER) 2 and 3. In this study, we show that NRG-1 activates the Janus kinases (JAK) and signal transducer and activator of transcription proteins (STAT). NRG-1 induced a rapid and transient increase in tyrosine phosphorylation of TYK2 and JAK3, but not JAK1 or JAK2, and induced STAT3 and STAT5 tyrosine phosphorylation PubMed:12204892

act(p(SFAM:"STAT5 Family"), ma(tscript)) increases bp(GOBP:"cell proliferation")

The signaling pathway of type I IFNs activates STAT1 and STAT2. In primary endothelial cells, we demonstrate that STAT3 and STAT5 are also activated, and these STATs may contribute to cellular proliferation PubMed:12759411

Sample Nodes


In-Edges: 173 | Out-Edges: 60 | Explore Neighborhood | Download JSON

p(SFAM:"STAT5 Family")

In-Edges: 123 | Out-Edges: 61 | Explore Neighborhood | Download JSON


In-Edges: 441 | Out-Edges: 466 | Explore Neighborhood | Download JSON


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