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Parkinsonian Disorders

Name
Parkinsonian Disorders
Namespace Keyword
MeSHDisease
Namespace
MeSH
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-diseases/mesh-diseases-20170511.belanno

Sample Annotated Edges 3

p(HGNC:PRKN, var("?")) decreases act(p(HGNC:PRKN)) View Subject | View Object

An interesting finding is that not all mutations found in Parkin in AR-JP patients are inactivatingmutations (see,for example, Chung et al., 2001; Corti et al., 2003; Imai et al., 2001 PubMed:14556719

Appears in Networks:
Annotations
MeSH
Parkinsonian Disorders

p(HGNC:PRKN, var("?")) causesNoChange deg(p(HGNC:SNCA)) View Subject | View Object

Therefore, patients with AR-JP—who cannot degrade it because of the mutation in the Parkin E3 (see above)—develop neurodegeneration PubMed:14556719

Appears in Networks:
Annotations
MeSH
Parkinsonian Disorders

path(MESH:"Parkinsonian Disorders") increases path(HBP:Neurodegeneration) View Subject | View Object

Therefore, patients with AR-JP—who cannot degrade it because of the mutation in the Parkin E3 (see above)—develop neurodegeneration PubMed:14556719

Appears in Networks:
Annotations
MeSH
Parkinsonian Disorders

Showing 3 of 3 edges

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.