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Substantia Nigra

Name
Substantia Nigra
Namespace Keyword
MeSHAnatomy
Namespace
MeSH
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-anatomy/mesh-anatomy-20170511.belanno

Sample Annotated Edges 5

act(p(FPLX:CHRN)) increases act(a(MESH:"Dopaminergic Neurons")) View Subject | View Object

In substantia nigra, postsynaptic nicotinic receptors induce inward currents to excite dopaminergic neurons that project to corpus striatum (Matsubayashi et al., 2003) PubMed:28445721

Appears in Networks:
Annotations
MeSH
Substantia Nigra

path(MESH:Dementia) positiveCorrelation a(GO:"Lewy body") View Subject | View Object

In this dementia, Lewy bodies are abundant in cortical neurons, especially in the cingulate gyrus, in addition to their presence in the substantia nigra and locus ceruleus, their prototypical loci in Parkinson’s disease. PubMed:22908190

Appears in Networks:
Annotations
MeSH
Cerebral Cortex
MeSH
Gyrus Cinguli
MeSH
Locus Coeruleus
MeSH
Neurons
MeSH
Substantia Nigra
MeSH
Parkinson Disease

a(GO:"Lewy body") positiveCorrelation path(MESH:Dementia) View Subject | View Object

In this dementia, Lewy bodies are abundant in cortical neurons, especially in the cingulate gyrus, in addition to their presence in the substantia nigra and locus ceruleus, their prototypical loci in Parkinson’s disease. PubMed:22908190

Appears in Networks:
Annotations
MeSH
Cerebral Cortex
MeSH
Gyrus Cinguli
MeSH
Locus Coeruleus
MeSH
Neurons
MeSH
Substantia Nigra
MeSH
Parkinson Disease

p(HGNC:MAPT) increases a(MESH:Neurons) View Subject | View Object

Intraneuronal iron accumulation, neuronal loss in the substantia nigra and a severe decline in locomotor functions were observed in 12‑month-old tau-knockoutmice PubMed:26631930

Appears in Networks:
Annotations
MeSH
Substantia Nigra

path(MESH:"Parkinson Disease") increases a(CHEBI:"iron(0)") View Subject | View Object

Notably, this accumulation of iron was observed in the brain regions with reduced soluble tau levels, such as the cortex in AD, the substantia nigra in PD and various brain regions in several other tauopathies PubMed:26631930

Appears in Networks:
Annotations
MeSH
Substantia Nigra

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About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.