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basal nucleus of telencephalon

Name
basal nucleus of telencephalon
Namespace Keyword
Anatomy
Namespace
Uberon
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/anatomy/anatomy-20170511.belanno

Sample Annotated Edges 5

p(HBP:RAC1b) association p(HGNC:NGFR) View Subject | View Object

CBF tissues harvested from people who died with a clinical diagnosis of no cognitive impairment (NCI), mild cognitive impairment, or AD were immunolabeled for both p75NTR and Rac1b. Rac1b appeared as cytoplasmic diffuse granules, loosely aggregated filaments, or compact spheres in p75NTR-positive NB neurons. Although Rac1b colocalized with tau cytoskeletal markers, the percentage of p75NTR-immunoreactive neurons expressing Rac1b was significantly increased only in AD compared with both mild cognitive impairment and NCI. PubMed:22142809

Appears in Networks:
Annotations
Uberon
basal nucleus of telencephalon
Cell Ontology (CL)
cholinergic neuron
Disease Ontology (DO)
Alzheimer's disease

p(HBP:RAC1b) negativeCorrelation p(HGNC:CAV2) View Subject | View Object

Furthermore, single-cell gene expression profiling with custom-designed microarrays showed down-regulation of caveolin 2, GNB4, and lipase A in AD Rac1b-positive/p75NTR-labeled NB neurons compared with Rac1b-negative/p75NTRpositive perikarya in NCI. These proteins are involved in Rac1 pathway/cell cycle progression and lipid metabolism. PubMed:22142809

Appears in Networks:
Annotations
Uberon
basal nucleus of telencephalon
Cell Ontology (CL)
cholinergic neuron
Disease Ontology (DO)
Alzheimer's disease

p(HBP:RAC1b) negativeCorrelation p(HGNC:GNB4) View Subject | View Object

Furthermore, single-cell gene expression profiling with custom-designed microarrays showed down-regulation of caveolin 2, GNB4, and lipase A in AD Rac1b-positive/p75NTR-labeled NB neurons compared with Rac1b-negative/p75NTRpositive perikarya in NCI. These proteins are involved in Rac1 pathway/cell cycle progression and lipid metabolism. PubMed:22142809

Appears in Networks:
Annotations
Uberon
basal nucleus of telencephalon
Cell Ontology (CL)
cholinergic neuron
Disease Ontology (DO)
Alzheimer's disease

p(HBP:RAC1b) negativeCorrelation p(HGNC:LIPA) View Subject | View Object

Furthermore, single-cell gene expression profiling with custom-designed microarrays showed down-regulation of caveolin 2, GNB4, and lipase A in AD Rac1b-positive/p75NTR-labeled NB neurons compared with Rac1b-negative/p75NTRpositive perikarya in NCI. These proteins are involved in Rac1 pathway/cell cycle progression and lipid metabolism. PubMed:22142809

Appears in Networks:
Annotations
Uberon
basal nucleus of telencephalon
Cell Ontology (CL)
cholinergic neuron
Disease Ontology (DO)
Alzheimer's disease

p(HGNC:CAV2) negativeCorrelation p(HBP:RAC1b) View Subject | View Object

Furthermore, single-cell gene expression profiling with custom-designed microarrays showed down-regulation of caveolin 2, GNB4, and lipase A in AD Rac1b-positive/p75NTR-labeled NB neurons compared with Rac1b-negative/p75NTRpositive perikarya in NCI. These proteins are involved in Rac1 pathway/cell cycle progression and lipid metabolism. PubMed:22142809

Appears in Networks:
Annotations
Uberon
basal nucleus of telencephalon
Cell Ontology (CL)
cholinergic neuron
Disease Ontology (DO)
Alzheimer's disease

Showing 5 of 8 edges

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.