a(HBP:HBP00074) decreases bp(GO:memory)

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PubMed:29196815

In normal rats, impaired memory of a learned behavior was observed after intraventricular application of soluble oligomers of Aβ42 isolated directly from human AD brains (Shankar et al. 2008). Furthermore, AβO injections resulted in reduction of a synapse number and their function in dose-dependent manner. It also led to the inhibition of LTP and enhancement of long-term synaptic depression (LTD) in rodent hippocampus (Shankar et al. 2008).

Related Edges 4

• a(HBP:HBP00074) decreases a(MESH:Synapses)
• a(HBP:HBP00074) decreases bp(GO:"long-term synaptic potentiation")
• a(HBP:HBP00074) decreases bp(GO:"signal release from synapse")
• a(HBP:HBP00074) increases bp(GO:"long term synaptic depression")

MeSH

Extracellular Space

Cell Ontology (CL)

neuron

Confidence

High

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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