a(CHEBI:"nitric oxide") increases bp(GO:vasoconstriction)

PubMed:28314763

The extensive crosslinkage of cell-free hemoglobin in a high-molecular weight HBOC retains cell-free hemoglobin dimers in the intravascular compartment, thereby preventing extravasation 112 of cell-free hemoglobin into the muscular layer of the arteries where local NO consumption can trigger vasoconstriction (25).

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