path(MESH:Inflammation) positiveCorrelation bp(GO:"inflammatory response")

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PubMed:26675351

Our data support the idea that heme-induced phenotypic switching of macrophages toward a proinflammatory phenotype can contribute to the exacerbation of inflammation and chronic tissue injury in hemolytic disorders and that Hx therapy could alleviate these pathophysiologic consequences by preventing macrophage inflammatory activation.

Related Edges 8

• a(CHEBI:heme) increases bp(HM:"macrophage M1 polarization")
• bp(GO:"inflammatory response") negativeCorrelation p(MGI:Hpx)
• bp(GO:"inflammatory response") positiveCorrelation bp(HM:"macrophage M1 polarization")
• bp(GO:"inflammatory response") positiveCorrelation path(MESH:Inflammation)
• bp(HM:"macrophage M1 polarization") negativeCorrelation p(MGI:Hpx)
• bp(HM:"macrophage M1 polarization") positiveCorrelation bp(GO:"inflammatory response")
• p(MGI:Hpx) negativeCorrelation bp(GO:"inflammatory response")
• p(MGI:Hpx) negativeCorrelation bp(HM:"macrophage M1 polarization")

Cell Ontology (CL)

macrophage

MeSH

Liver

MeSH

Anemia, Sickle Cell

Text Location

Discussion

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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