act(p(HGNC:UCHL1)) decreases p(HGNC:BACE1)

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PubMed:27288790

Aβ 42 mediated increase in BACE1 expression is accompanied by a decrease in Uch-L1 expression and activity in dif- ferent cellular models and in sporadic AD brains, which interferes with the lysosomal degradation of BACE1 [52,56].

Related Edges 2

• a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:BACE1)
• p(HGNC:UCHL1) decreases p(HGNC:BACE1)

MeSH

Brain

MeSH

Alzheimer Disease

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