act(p(HGNC:TLR4)) positiveCorrelation bp(GO:"inflammatory response")

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PubMed:29694434

The released heme can activate the innate immune pattern recognition receptor toll-like receptor 4 (TLR4) on inflammatory cells, platelets and endothelium, promoting a pro-inflammatory and pro-coagulant phenotype, ultimately leading to vaso-occlusion, ischemia-reperfusion physiology, tissue injury, and pain in murine models of SCD [5, 7±10].

Related Edges 9

• a(CHEBI:heme) positiveCorrelation path(MESH:"Reperfusion Injury")
• a(CHEBI:heme) positiveCorrelation act(p(HGNC:TLR4))
• a(CHEBI:heme) positiveCorrelation path(HM:"vaso-occlusive crisis")
• a(CHEBI:heme) positiveCorrelation path(MESH:Pain)
• bp(GO:"inflammatory response") positiveCorrelation act(p(HGNC:TLR4))
• act(p(HGNC:TLR4)) positiveCorrelation a(CHEBI:heme)
• path(HM:"vaso-occlusive crisis") positiveCorrelation a(CHEBI:heme)
• path(MESH:"Reperfusion Injury") positiveCorrelation a(CHEBI:heme)
• path(MESH:Pain) positiveCorrelation a(CHEBI:heme)

MeSH

Blood Platelets

MeSH

Anemia, Sickle Cell

Text Location

Introduction

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