a(CHEBI:heme) increases p(MGI:Vwf)

View Subject View Object

PubMed:24904418

Heme activates endothelial cells inducing the expression of the adhesion molecules ICAM-1 (intercellular adhesion molecule 1), VCAM-1 (vascular cell adhesion molecule 1), E-selectin, Pselectin, and von Willebrand factor (VWF; Wagener et al., 1997; Belcher et al., 2014) and causes neutrophil migration (GraçaSouza et al., 2002; Porto et al., 2007).

Related Edges 6

• a(CHEBI:heme) increases p(MGI:Icam1)
• a(CHEBI:heme) increases p(MGI:Vcam1)
• a(CHEBI:heme) increases bp(GO:"endothelial cell activation")
• a(CHEBI:heme) increases p(HGNC:SELE)
• a(CHEBI:heme) increases p(HGNC:SELP)
• a(CHEBI:heme) increases bp(GO:"neutrophil migration")

Cell Ontology (CL)

erythrocyte

Text Location

Review

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---