path(MESH:Sleep) increases act(a(MESH:"Blood-Brain Barrier"))

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PubMed:26195256

Thus, sleep could indirectly increase BBB clearance of Aβ through increased glymphatic bulk flow, but it might also directly increase clearance through the BBB via various mechanisms, such as molecular changes (for example, upregulated LRP1), as seen with AD-protective physical and cognitive activity in mice.1

Related Edges 1

• path(MESH:Sleep) increases bp(HBP:"glymphatic bulk flow")

MeSH

Hippocampus

MeSH

Temporal Lobe

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