a(TAXONOMY:33113) increases a(CHEBI:atropine)

PubMed:19126755

The metabotropic receptors are second messenger, G protein-coupled seven-transmembrane proteins. They are classically defined as being activated by muscarine, a toxin from the mushroom Amanita muscaria, and inhibited by atropine, a toxin from Atropa belladonna, a member of the nightshade family. Both toxins cross the blood-brain barrier poorly and were discovered primarily from their influences on postganglionic parasympathetic nervous system functions. Activation of muscarinic AChRs is relatively slow (milliseconds to seconds) and, depending on the subtypes present (M1- M5), they directly alter cellular homeostasis of phospholipase C, inositol trisphosphate, cAMP, and free calcium.

Related Edges 7

• a(CHEBI:Muscarine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic"))
• a(CHEBI:atropine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic"))
• a(TAXONOMY:41956) increases a(CHEBI:Muscarine)
• act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates p(FPLX:PLC)
• act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates a(CHEBI:"3',5'-cyclic AMP")
• act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates a(CHEBI:"myo-inositol trisphosphate")
• act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates a(CHEBI:"calcium ion")

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