a(MESH:Macrophages) regulates deg(a(CHEBI:"amyloid-beta"))

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PubMed:30046111

By contrast, the parenchyma of the CNS is devoid of lymphatic vasculature2; in the brain, removal of cellular debris and toxic molecules, such as amyloid-β peptides, is mediated by a combination of transcellular transport mechanisms across the blood−brain and blood−cerebrospinal fluid (CSF) barriers7–9, phagocytosis and digestion by resident microglia and recruited monocytes and/or macrophages10,11, as well as CSF influx and ISF efflux through a paravascular (glymphatic) route12–14

Related Edges 4

• tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:Blood), toLoc(MESH:"Cerebrospinal Fluid")) regulates deg(a(CHEBI:"amyloid-beta"))
• a(MESH:Microglia) regulates deg(a(CHEBI:"amyloid-beta"))
• a(MESH:Monocytes) regulates deg(a(CHEBI:"amyloid-beta"))
• bp(GO:phagocytosis) regulates deg(a(CHEBI:"amyloid-beta"))

Confidence

High

MeSH

Brain

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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