a(MESH:Nicotine) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)))

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PubMed:28901280

Chronic nicotine treatment also activates the α7 receptors expressed on glutamatergic terminals, increases the release of glutamate (which facilitates the burst firing of VTA DA neurons), increases NMDA receptor activity, and LTP [79], but simultaneosusly induces the desensitisation of the α4β2 receptors on GABAergic terminals. Overall, these effects decrease the inhibition onto DA neurons, and increase DA release in the NAc [82].

Related Edges 5

• a(MESH:Nicotine) increases a(MESH:Glutamates)
• a(MESH:Nicotine) increases a(MESH:Dopamine)
• a(MESH:Nicotine) increases act(p(HGNC:CHRNA7))
• a(MESH:Nicotine) increases p(MESH:"Receptors, N-Methyl-D-Aspartate")
• a(MESH:Nicotine) increases bp(MESH:"Long-Term Potentiation")

MeSH

GABAergic Neurons

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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