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PubMed: 14963027

Title
Binding of tau to heat shock protein 27 leads to decreased concentration of hyperphosphorylated tau and enhanced cell survival.
Journal
The Journal of biological chemistry
Volume
279
Issue
None
Pages
17957-62
Date
2004-04-23
Authors
Shimura H | Miura-Shimura Y | Kosik KS

Evidence f131d479f2
JSON

Taken together, pathological hyperphosphorylated tau caused cell death, and Hsp27 attenuated the cell toxicity of pathological hyperphosphorylated tau.

bp(GO:"neuron apoptotic process") negativeCorrelation p(HGNC:HSPB1) View Subject | View Object

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temporal cortex

p(HGNC:HSPB1) decreases act(p(HGNC:MAPT, pmod(Ph))) View Subject | View Object

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temporal cortex

p(HGNC:HSPB1) negativeCorrelation bp(GO:"neuron apoptotic process") View Subject | View Object

Appears in Networks:
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Uberon
temporal cortex

act(p(HGNC:MAPT, pmod(Ph))) increases bp(GO:"neuron apoptotic process") View Subject | View Object

Appears in Networks:
Annotations
Uberon
temporal cortex

Evidence 4741e02229
JSON

Here we show that heat shock protein 27 (Hsp27) preferentially binds pathological hyperphosphorylated tau and paired helical filaments tau directly but not non-phosphorylated tau. The formation of this complex altered the conformation of pathological hyperphosphorylated tau and reduced its concentration by facilitating its degradation and dephosphorylation.

complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) increases deg(p(HGNC:MAPT, pmod(Ph))) View Subject | View Object

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Uberon
temporal cortex

complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) increases rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) View Subject | View Object

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temporal cortex

p(HGNC:HSPB1) association p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

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Uberon
temporal cortex

p(HGNC:HSPB1) causesNoChange p(HGNC:MAPT) View Subject | View Object

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Uberon
temporal cortex

p(HGNC:HSPB1) increases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) View Subject | View Object

Appears in Networks:
Annotations
Uberon
temporal cortex

p(HGNC:MAPT, pmod(Ph)) association p(HGNC:HSPB1) View Subject | View Object

Appears in Networks:
Annotations
Uberon
temporal cortex

p(HGNC:MAPT, pmod(Ph)) increases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) View Subject | View Object

Appears in Networks:
Annotations
Uberon
temporal cortex

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