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PubMed: 22807490

Title
Anatabine ameliorates experimental autoimmune thyroiditis.
Journal
Endocrinology
Volume
153
Issue
None
Pages
4580-7
Date
2012-09-01
Authors
Caturegli P | De Remigis A | Ferlito M | Iwama S | Ladenson PW | Landek-Salgado MA | Tzou SC

Evidence c065c0068f
JSON

Furthermore, anatabine has been recently shown to inhibit nuclear factor-kB(NF-kB) activation and reduce neuroinflammation in a mouse model of Alzheimer disease (15).

a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB)) View Subject | View Object

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MeSH
Alzheimer Disease

a(CHEBI:Anatabine) decreases bp(GO:"inflammatory response") View Subject | View Object

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MeSH
Neurons
MeSH
Alzheimer Disease

Evidence 218a6f54ad
JSON

Anatabine significantly decreased the severity of EAT induced with our standard induction protocol.

a(CHEBI:Anatabine) decreases path(MESH:"Thyroiditis, Autoimmune") View Subject | View Object

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Evidence 035180bcda
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Anatabine treated mice developed lower levels of thyroglobulin antibodies than controls on d 14 (P  0.029) and d 21 (P  0.045) (Fig. 2A), suggesting that anatabine atten- uates the thyroid-specific autoimmune response in- duced by thyroglobulin immunization.

a(CHEBI:Anatabine) decreases a(MESH:Thyroglobulin) View Subject | View Object

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MeSH
Thyroiditis, Autoimmune

Evidence 5a56fb6132
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Anatabine suppressed the EAT-mediated increase of IL-1 receptor type 2 (IL-1R2, Figure 3A) and IL-18 (Fig. 3B), restoring their expression to levels similar to those seen in normal unimmunized thyroids.

a(CHEBI:Anatabine) decreases p(HGNC:IL1R2) View Subject | View Object

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path(MESH:"Thyroiditis, Autoimmune") increases p(HGNC:IL1R2) View Subject | View Object

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Evidence 8bf49ae208
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Anatabine suppressed in a dose- dependent manner the increase of iNOS and COX2 in- duced by interferon-g (Fig.4),confirming in vitro its antiinflammatory properties. The effect seen with inter- feron-g was also seen when macrophages were stimulated with lipopolysaccharide (Supplemental Fig. 1).

a(CHEBI:Anatabine) decreases p(HGNC:NOS2) View Subject | View Object

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a(CHEBI:Anatabine) decreases p(HGNC:PTGS2) View Subject | View Object

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a(CHEBI:Anatabine) decreases bp(GO:"macrophage activation") View Subject | View Object

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a(CHEBI:lipopolysaccharide) increases bp(GO:"macrophage activation") View Subject | View Object

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p(HGNC:IFNG) increases p(HGNC:NOS2) View Subject | View Object

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p(HGNC:IFNG) increases p(HGNC:PTGS2) View Subject | View Object

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Evidence 82c5c2e83f
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Smokers in the Third National Health and Nutri- tion Examination Survey were found to have lower prev- alence of thyroperoxidase and/or thyroglobulin antibod- ies than nonsmokers (1).

p(HGNC:TPO) negativeCorrelation path(MESH:Smoking) View Subject | View Object

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path(MESH:Smoking) negativeCorrelation p(HGNC:TPO) View Subject | View Object

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Evidence dd9296a246
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Tobacco smoking has numerous detrimental effects on human health, but it has also been associated with a few apparent salutary actions, including the amelioration of autoimmune (Hashimoto) thyroiditis and ulcerative colitis.

path(MESH:"Colitis, Ulcerative") association path(MESH:Smoking) View Subject | View Object

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path(MESH:"Hashimoto Disease") association path(MESH:Smoking) View Subject | View Object

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path(MESH:Smoking) association path(MESH:"Hashimoto Disease") View Subject | View Object

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path(MESH:Smoking) association path(MESH:"Colitis, Ulcerative") View Subject | View Object

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