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PubMed: 22057784

Title
Selective tau tyrosine nitration in non-AD tauopathies.
Journal
Acta neuropathologica
Volume
123
Issue
None
Pages
119-32
Date
2012-01-01
Authors
Binder LI | Geula C | Reyes JF | Vana L

Evidence e73a8b2aab
JSON

Tau-nY18 did not label the classical pathological lesions of CBD or PSP but did label the neuronal lesions associated with PiD. Tau-nY29 revealed some, but not all classes of tau inclusions associated with both CBD and PSP but did label numerous Pick body inclusions in PiD. Tau-nY197 was restricted to the neuropil threads in both CBD and PSP; however, similar to Tau-nY29, extensive Pick body pathology was clearly labeled. Tau-nY394 did not detect any of the lesions associated with these disorders.

p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation path(MESH:"Pick Disease of the Brain") View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") View Subject | View Object

Appears in Networks:
Annotations
Uberon
neuropil
Disease Ontology (DO)
progressive supranuclear palsy

p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) positiveCorrelation path(HBP:"Corticobasal Degeneration") View Subject | View Object

Appears in Networks:
Annotations
Uberon
neuropil
Disease Ontology (DO)
progressive supranuclear palsy

p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation path(MESH:"Pick Disease of the Brain") View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(NO, Tyr, 29)) positiveCorrelation path(MESH:"Pick Disease of the Brain") View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
progressive supranuclear palsy
MeSH
Pick Disease of the Brain

path(HBP:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
neuropil
Disease Ontology (DO)
progressive supranuclear palsy

path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) View Subject | View Object

Appears in Networks:

path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) View Subject | View Object

Appears in Networks:

path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT, pmod(NO, Tyr, 29)) View Subject | View Object

Appears in Networks:
Annotations
Disease Ontology (DO)
progressive supranuclear palsy
MeSH
Pick Disease of the Brain

path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
neuropil
Disease Ontology (DO)
progressive supranuclear palsy

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