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PubMed: 25673844

Title
Phosphorylation of synaptic vesicle protein 2A at Thr84 by casein kinase 1 family kinases controls the specific retrieval of synaptotagmin-1.
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume
35
Issue
None
Pages
2492-507
Date
2015-02-11
Authors
Alessi DR | Campbell DG | Cousin MA | Esoof N | Fritsch MJ | Gordon SL | Gourlay R | Macartney T | Peggie M | Velupillai S | Zhang N | van Aalten DM

Evidence 4ff809b87a
JSON

We demonstrate that Casein kinase 1 family members, including isoforms of Tau-tubulin protein kinases (TTBK1 and TTBK2), phosphorylate human SV2A at two constellations of residues, namely Cluster-1 (Ser42, Ser45, and Ser47) and Cluster-2 (Ser80, Ser81, and Thr84). These residues are also phosphorylated in vivo, and the phosphorylation of Thr84 within Cluster-2 is essential for triggering binding to the C2B domain of human synaptotagmin-1

p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 80)) View Subject | View Object

Appears in Networks:

p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 42)) View Subject | View Object

Appears in Networks:

p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 45)) View Subject | View Object

Appears in Networks:

p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 47)) View Subject | View Object

Appears in Networks:

p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 81)) View Subject | View Object

Appears in Networks:

p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Thr, 84)) View Subject | View Object

Appears in Networks:

p(HGNC:SV2A, pmod(Ph, Thr, 84)) association p(HGNC:SYT1) View Subject | View Object

Appears in Networks:

p(HGNC:SYT1) association p(HGNC:SV2A, pmod(Ph, Thr, 84)) View Subject | View Object

Appears in Networks:

p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 42)) View Subject | View Object

Appears in Networks:

p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 45)) View Subject | View Object

Appears in Networks:

p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 47)) View Subject | View Object

Appears in Networks:

p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 80)) View Subject | View Object

Appears in Networks:

p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 81)) View Subject | View Object

Appears in Networks:

p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Thr, 84)) View Subject | View Object

Appears in Networks:

p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 42)) View Subject | View Object

Appears in Networks:

p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 45)) View Subject | View Object

Appears in Networks:

p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 47)) View Subject | View Object

Appears in Networks:

p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 80)) View Subject | View Object

Appears in Networks:

p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 81)) View Subject | View Object

Appears in Networks:

p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Thr, 84)) View Subject | View Object

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.