p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Thr, 84))

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PubMed:25673844

We demonstrate that Casein kinase 1 family members, including isoforms of Tau-tubulin protein kinases (TTBK1 and TTBK2), phosphorylate human SV2A at two constellations of residues, namely Cluster-1 (Ser42, Ser45, and Ser47) and Cluster-2 (Ser80, Ser81, and Thr84). These residues are also phosphorylated in vivo, and the phosphorylation of Thr84 within Cluster-2 is essential for triggering binding to the C2B domain of human synaptotagmin-1

Related Edges 19

• p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 80))
• p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 42))
• p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 45))
• p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 47))
• p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 81))
• p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Thr, 84))
• p(HGNC:SV2A, pmod(Ph, Thr, 84)) association p(HGNC:SYT1)
• p(HGNC:SYT1) association p(HGNC:SV2A, pmod(Ph, Thr, 84))
• p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 42))
• p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 45))
• p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 47))
• p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 80))
• p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 81))
• p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Thr, 84))
• p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 42))
• p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 45))
• p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 47))
• p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 80))
• p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 81))

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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