Title

Tau-tubulin kinase.

Journal

Frontiers in molecular neuroscience

Volume

7

Issue

None

Pages

33

Date

2014-01-01

Authors

Ikezu S | Ikezu T

Overexpression of TTBK1 was sufficient in inducing spatial learning impairment in mice, which is associated with enhanced Cdk5 activity and reduction in cell surface level of NR2B. Over-expressionof TTBK1 transgene in JNPL3 mice resulted in accumulation of pre-tangle forms of tau. Inaddition, TTBK1 expression plays a unique role in accelerating motor neuron degeneration and neuroinflammation in JNPL3mice.

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