bp(GO:learning) negativeCorrelation p(MGI:Ttbk1)

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PubMed:24808823

Overexpression of TTBK1 was sufficient in inducing spatial learning impairment in mice, which is associated with enhanced Cdk5 activity and reduction in cell surface level of NR2B. Over-expressionof TTBK1 transgene in JNPL3 mice resulted in accumulation of pre-tangle forms of tau. Inaddition, TTBK1 expression plays a unique role in accelerating motor neuron degeneration and neuroinflammation in JNPL3mice.

Related Edges 7

• bp(GO:learning) negativeCorrelation p(MGI:Cdk5)
• bp(GO:learning) positiveCorrelation surf(p(MGI:Grin2b))
• p(MGI:Cdk5) negativeCorrelation bp(GO:learning)
• surf(p(MGI:Grin2b)) positiveCorrelation bp(GO:learning)
• p(MGI:Ttbk1) negativeCorrelation bp(GO:learning)
• p(MGI:Ttbk1) increases a(HBP:pretangles)
• p(MGI:Ttbk1) increases bp(GO:"neuron death")

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