PubMed: 16820021

Title
The CRF1 receptor antagonist, antalarmin, reverses isolation-induced up-regulation of dopamine D2 receptors in the amygdala and nucleus accumbens of fawn-hooded rats.
Journal
The European journal of neuroscience
Volume
23
Issue
None
Pages
3319-27
Date
2006-06-01
Authors
Lawrence AJ | Lodge DJ | Card K | Djouma E

Evidence 1cf05f1946

Autoradiographic detection of dopamine D1 receptors by [125I]- SCH 23982 was fully displaceable by the agonist SKF-77434.

Evidence 33f41768ff

Overall, no changes were observed in dopamine D1 receptor binding in the brain regions examined following social isolation and ⁄ or antalarmin treatment under these conditions

Evidence d294f59a21

antalarmin increased dopamine D2 ⁄ 3 binding in the CPu (+7%, P < 0.001; Fig. 3C) and olfactory tubercle (OT; +15%, P 1⁄4 0.006; Fig. 3D) of group-housed rats.

Evidence 1cd530eae7

Antalar- min treatment reversed this effect and returned dopamine D2 ⁄ 3 receptor density levels back to those of the vehicle-treated GH rats.

Evidence d8c4f9f1b6

Furthermore a significant interaction was found between housing and treatment in both the central nucleus of the amygdala (CeA; F1,139 1⁄4 11.560, P < 0.001; Fig. 3F) and basolateral amygdala (BLA; F1,137 1⁄4 7.616, P 1⁄4 0.007; Fig. 3E).Thus, isolation caused an up-regulation in dopamine D2 ⁄ 3 receptors in these regions, an effect that was reversed by antalarmin treatment (but only reached statistical significance in the CeA).

Evidence 2a7478dd0f

Treatment with antalarmin had no impact upon the isolation-induced alterations of BDNF expression.

Evidence 4a9ada78d3

As was the case with BDNF expression, treatment with antalarmin had no impact upon the isolation-induced alterations in TrkB expression.

Evidence 9b03e4132d

Interestingly however, antalarmin treatment of GH rats caused a down-regulation of TrkB mRNA in the LC ()15%, P 1⁄4 0.012) and Pir ()26%, P 1⁄4 0.013) whilst increases were observed in the hippocampus (CA1–3; +36%, P 1⁄4 0.042) and RSc (+53%, P < 0.001).

Evidence fc47d4b2cd

Isolation rearing caused an up-regulation of dopamine D2 ⁄ 3 receptors in both the core (+20%; F1,144 1⁄4 31.176, P < 0.001; Fig. 3A) and shell (+25%; F1,148 1⁄4 35.233, P < 0.001; Fig. 3B) of the NAcc.

Evidence 57ea57087e

A significant decrease in BDNF mRNA expression resulting from ISO was found in the BLA ()25%; F1,102 1⁄4 77.937, P < 0.001), nucleus of the horizontal limb of the diagonal band (HB )75%; F1,67 1⁄4 259.106, P < 0.001) and dentate gyrus (DG )85%; F1,101 1⁄4 984.958,

Evidence b8fa1ca2fa

whilst isolation increased BDNF mRNA expression in the retrosplenial cortex

Evidence b981725f8f

ISO resulted in a decrease in TrkB mRNA expression in the cingulate cortex (Cg1–3; F1,124 1⁄4 7.582, P 1⁄4 0.014) and piriform cortex (Pir; F1,119 1⁄4 3.869

Evidence eb8155d64c

whereas an increase was observed in isolates compared to GH in the hippocampus (+38%; F1,59 1⁄4 14.131, P < 0.001), DG (+32%; F1,56 1⁄4 8.398, P 1⁄4 0.005) and RSc (+32%; F1,56 1⁄4 6.830, P 1⁄4 0.011).

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