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PubMed: 28632203

Title
Combined assessment of DYRK1A, BDNF and homocysteine levels as diagnostic marker for Alzheimer's disease.
Journal
Translational psychiatry
Volume
7
Issue
None
Pages
e1154
Date
2017-06-20
Authors
Potier MC | Janel N | Delabar JM | Alexopoulos P | Arbones M | Badel A | Camproux AC | Dubois B | Feraudet-Tarisse C | Lagarde J | Lamari F | Lamourette P | Paul JL | Sarazin M | Simon S

Evidence 810d7aba85
JSON

Receiver-operating characteristic curves and logistic regression analyses showed that combined assessment of DYRK1A, BDNF and homocysteine has a sensitivity of 0.952, a specificity of 0.889 and an accuracy of 0.933 in testing for AD. The blood levels of these markers provide a diagnosis assessment profile. Combined assessment of these three markers outperforms most of the previous markers and could become a useful substitute to the current panel of AD biomarkers.

a(CHEBI:homocysteine) biomarkerFor path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
Uberon
blood plasma
MeSH
Alzheimer Disease

composite(a(CHEBI:homocysteine), p(HGNC:BDNF), p(HGNC:DYRK1A)) biomarkerFor path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
Uberon
blood plasma
MeSH
Alzheimer Disease

p(HGNC:BDNF) biomarkerFor path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
Uberon
blood plasma
MeSH
Alzheimer Disease

p(HGNC:DYRK1A) biomarkerFor path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:
Annotations
Uberon
blood plasma
MeSH
Alzheimer Disease

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