Title

Effect of pseudophosphorylation and cross-linking by lipid peroxidation and advanced glycation end product precursors on tau aggregation and filament formation.

Journal

The Journal of biological chemistry

Volume

282

Issue

None

Pages

6984-91

Date

2007-03-09

Authors

Arendt T | Flach K | Haase C | Kuhla B | Lüth HJ | Münch G

Acrolein and methylglyoxal were the most reactive compounds followed by glyoxal and malondialdehyde in terms of formation of Tau dimers and higher molecular weight oligomers. Analysis of the Tau aggregates by electron microscopy study showed that formation of fibrils using wild-type Tau and several Tau mutants could be observed with acrolein and methylglyoxal but not with glyoxal and malondialdehyde.

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