a(CHEBI:methylglyoxal) increases a(GO:"neurofibrillary tangle")

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PubMed:17082178

Acrolein and methylglyoxal were the most reactive compounds followed by glyoxal and malondialdehyde in terms of formation of Tau dimers and higher molecular weight oligomers. Analysis of the Tau aggregates by electron microscopy study showed that formation of fibrils using wild-type Tau and several Tau mutants could be observed with acrolein and methylglyoxal but not with glyoxal and malondialdehyde.

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• a(CHEBI:acrolein) increases a(GO:"neurofibrillary tangle")

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