Title

A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy.

Journal

Scientific reports

Volume

7

Issue

None

Pages

44102

Date

2017-03-13

Authors

Cohen TJ | Madden V | Tripathy A | Trzeciakiewicz H | Tseng JH | Wander CM | Yuan CX

Thus, K → Q substitutions within the critical PHF6* motif, in the apparent absence of other tau PTMs, appears sufficient to accelerate tau aggregation in vitro.

Surprisingly, we show that tau acetylation alters phosphorylation at residues S202/T205 (comprising the AT8 epitope), indicating acetylation-dephosphorylation cross-talk. Using a series of biochemical approaches, we found that K280/K281 acetylation impaired tau-mediated MT assembly function and also significantly enhanced tau aggregation. We also demonstrate that methylene blue, a reported tau aggregation inhibitor, modulates tau acetylation, a novel mechanism of action for this class of compounds

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