p(HGNC:MAPT, pmod(Ac, Lys, 281)) decreases p(HGNC:MAPT, pmod(Ph, Thr, 205))

View Subject View Object

PubMed:28287136

Surprisingly, we show that tau acetylation alters phosphorylation at residues S202/T205 (comprising the AT8 epitope), indicating acetylation-dephosphorylation cross-talk. Using a series of biochemical approaches, we found that K280/K281 acetylation impaired tau-mediated MT assembly function and also significantly enhanced tau aggregation. We also demonstrate that methylene blue, a reported tau aggregation inhibitor, modulates tau acetylation, a novel mechanism of action for this class of compounds

Related Edges 3

• p(HGNC:MAPT, pmod(Ac, Lys, 280)) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202))
• p(HGNC:MAPT, pmod(Ac, Lys, 280)) increases a(HBP:"Tau aggregates")
• p(HGNC:MAPT, pmod(Ac, Lys, 281)) increases a(HBP:"Tau aggregates")

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---