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PubMed: 26400044

Title
Colocalization of phosphorylated forms of WAVE1, CRMP2, and tau in Alzheimer's disease model mice: Involvement of Cdk5 phosphorylation and the effect of ATRA treatment.
Journal
Journal of neuroscience research
Volume
94
Issue
None
Pages
15-26
Date
2016-01-01
Authors
Nikkuni M | Ohshima T | Toba J | Watamura N | Yoshii A

Evidence 037496fe41
JSON

ATRA prevents the accumulation of amyloid plaques and APP processing into Ab through downregulation of Cdk5 in APP/PS1 mice. These results suggested that the administration of ATRA inhibited activity of Cdk5 and GSK3b and attenuated the formation of p-tau aggregation, including p-CRMP2 and p-WAVE1 in the 33Tg mouse brain.

a(CHEBI:"all-trans-retinoic acid") decreases path(MESH:"Plaque, Amyloid") View Subject | View Object

Appears in Networks:

a(CHEBI:"all-trans-retinoic acid") decreases a(HBP:"APP processing") View Subject | View Object

Appears in Networks:

a(CHEBI:"all-trans-retinoic acid") decreases act(p(MGI:Cdk5), ma(kin)) View Subject | View Object

Appears in Networks:

a(CHEBI:"all-trans-retinoic acid") decreases act(p(MGI:Gsk3b), ma(kin)) View Subject | View Object

Appears in Networks:

a(CHEBI:"all-trans-retinoic acid") decreases complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) View Subject | View Object

Appears in Networks:

Evidence 85fcc8f6fd
JSON

First, we verified the colocalization of p-WAVE1 and pCRMP2 with aggregated hyperphosphorylated tau in the hippocampus at 23 months of age. Biochemical analysis revealed the inclusion of p-WAVE1, p-CRMP2, and tau in the sarkosyl-insoluble fractions of hippocampal homogenates

p(MGI:Mapt) increases complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation

act(p(MGI:Cdk5), ma(kin)) increases p(MGI:Wasf1, pmod(Ph)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation

act(p(MGI:Cdk5), ma(kin)) increases p(MGI:Dpysl2, pmod(Ph)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation

Evidence 42ac9297d9
JSON

We found that the immunoreactivities of p-WAVE1 and pCRMP2 colocalized with p-tau and were located near peripheral amyloid plaques in the cerebral cortices of 23- month-old 33Tg (Fig. 3A) and 17-month-old APPswe/ PS1DE9 (Fig. 3B) mice.

complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) association path(MESH:"Plaque, Amyloid") View Subject | View Object

Appears in Networks:
Annotations
Uberon
cerebral cortex

path(MESH:"Plaque, Amyloid") association complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) View Subject | View Object

Appears in Networks:
Annotations
Uberon
cerebral cortex

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