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complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph)))

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Components

Appears in Networks 1

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

In-Edges 5

a(CHEBI:"all-trans-retinoic acid") decreases complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) View Subject | View Object

ATRA prevents the accumulation of amyloid plaques and APP processing into Ab through downregulation of Cdk5 in APP/PS1 mice. These results suggested that the administration of ATRA inhibited activity of Cdk5 and GSK3b and attenuated the formation of p-tau aggregation, including p-CRMP2 and p-WAVE1 in the 33Tg mouse brain. PubMed:26400044

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p(MGI:Mapt) increases complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) View Subject | View Object

First, we verified the colocalization of p-WAVE1 and pCRMP2 with aggregated hyperphosphorylated tau in the hippocampus at 23 months of age. Biochemical analysis revealed the inclusion of p-WAVE1, p-CRMP2, and tau in the sarkosyl-insoluble fractions of hippocampal homogenates PubMed:26400044

Appears in Networks:
Annotations
Uberon
hippocampal formation

p(MGI:Dpysl2, pmod(Ph)) partOf complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) View Subject | View Object

Appears in Networks:

p(MGI:Wasf1, pmod(Ph)) partOf complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) View Subject | View Object

Appears in Networks:

path(MESH:"Plaque, Amyloid") association complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) View Subject | View Object

We found that the immunoreactivities of p-WAVE1 and pCRMP2 colocalized with p-tau and were located near peripheral amyloid plaques in the cerebral cortices of 23- month-old 33Tg (Fig. 3A) and 17-month-old APPswe/ PS1DE9 (Fig. 3B) mice. PubMed:26400044

Appears in Networks:
Annotations
Uberon
cerebral cortex

Out-Edges 4

complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) hasComponent p(MGI:Dpysl2, pmod(Ph)) View Subject | View Object

Appears in Networks:

complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) hasComponent p(MGI:Mapt) View Subject | View Object

Appears in Networks:

complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) hasComponent p(MGI:Wasf1, pmod(Ph)) View Subject | View Object

Appears in Networks:

complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) association path(MESH:"Plaque, Amyloid") View Subject | View Object

We found that the immunoreactivities of p-WAVE1 and pCRMP2 colocalized with p-tau and were located near peripheral amyloid plaques in the cerebral cortices of 23- month-old 33Tg (Fig. 3A) and 17-month-old APPswe/ PS1DE9 (Fig. 3B) mice. PubMed:26400044

Appears in Networks:
Annotations
Uberon
cerebral cortex

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.