a(CHEBI:"all-trans-retinoic acid") decreases path(MESH:"Plaque, Amyloid")

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PubMed:26400044

ATRA prevents the accumulation of amyloid plaques and APP processing into Ab through downregulation of Cdk5 in APP/PS1 mice. These results suggested that the administration of ATRA inhibited activity of Cdk5 and GSK3b and attenuated the formation of p-tau aggregation, including p-CRMP2 and p-WAVE1 in the 33Tg mouse brain.

Related Edges 4

• a(CHEBI:"all-trans-retinoic acid") decreases a(HBP:"APP processing")
• a(CHEBI:"all-trans-retinoic acid") decreases act(p(MGI:Cdk5), ma(kin))
• a(CHEBI:"all-trans-retinoic acid") decreases act(p(MGI:Gsk3b), ma(kin))
• a(CHEBI:"all-trans-retinoic acid") decreases complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph)))

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