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PubMed: 10464280

Title
Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathies.
Journal
The Journal of biological chemistry
Volume
274
Issue
None
Pages
25490-8
Date
1999-09-03
Authors
Brandt R | Bloom GS | Kuret J | Sontag E | Kamibayashi C | White CL 3rd | Lee G | Nunbhakdi-Craig V | Mumby MC

Evidence 1b9297df0a
JSON

ABaC binds directly to MTs through a site that encompasses its catalytic subunit and is distinct from its binding site for tau, and ABaC and tau bind to different domains on MTs.

complex(GO:microtubule) association p(HGNC:MAPT) View Subject | View Object

Appears in Networks:

complex(GO:microtubule) association p(HGNC:PPP2CA) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT) association complex(GO:microtubule) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT) increases complex(complex(GO:microtubule), p(HGNC:MAPT)) View Subject | View Object

Appears in Networks:

p(HGNC:PPP2CA) association complex(GO:microtubule) View Subject | View Object

Appears in Networks:

p(HGNC:PPP2CA) increases complex(complex(GO:microtubule), p(HGNC:PPP2CA)) View Subject | View Object

Appears in Networks:

Evidence 802c02b002
JSON

Using tau deletion mutants, we found that ABaC binds a domain on tau that is indistinguishable from its MT-binding domain.

act(complex(GO:microtubule)) positiveCorrelation p(HBP:"microtubule-binding region") View Subject | View Object

Appears in Networks:

act(complex(SCOMP:"PP2A Complex")) association p(HBP:"microtubule-binding region") View Subject | View Object

Appears in Networks:

p(HBP:"microtubule-binding region") association act(complex(SCOMP:"PP2A Complex")) View Subject | View Object

Appears in Networks:

p(HBP:"microtubule-binding region") positiveCorrelation act(complex(GO:microtubule)) View Subject | View Object

Appears in Networks:

Evidence 71ed5b1923
JSON

Thus, MTs inhibited the rate of tau dephosphorylation by ABaC.

act(complex(GO:microtubule)) directlyDecreases act(complex(SCOMP:"PP2A Complex")) View Subject | View Object

Appears in Networks:

act(complex(SCOMP:"PP2A Complex")) increases rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(Ph)) negativeCorrelation rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) View Subject | View Object

Appears in Networks:

rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

Appears in Networks:

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