1. Catalog
  2. Nodes
  3. p(HGNC:ZC3H14)

p(HGNC:ZC3H14)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
ZC3H14
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Caenorhabditis elegans models of tauopathy v1.0.0

In-Edges 1

composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:ZC3H14)) hasComponent p(HGNC:ZC3H14) View Subject | View Object

Appears in Networks:

Out-Edges 2

p(HGNC:ZC3H14) increases path(MESH:Tauopathies) View Subject | View Object

Homologs of SUT-2 exist in higher animals, including humans (MSUT-2), and reducing the MSUT-2 levels was found to be protective against tau-induced toxicity in a cell model (121). PubMed:29191965

Appears in Networks:

p(HGNC:ZC3H14) regulates bp(GO:"aggresome assembly") View Subject | View Object

Although a direct mechanism by which SUT-2 acts is not known, functional evidence of its binding partner ZYG-12 (122) suggests that it may act via modulating the aggresome formation by ZYG-12 (123,124). PubMed:29191965

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.