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p(HGNCGENEFAMILY:"Small heat shock proteins")

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Entity

Name
Small heat shock proteins
Namespace
hgnc.genefamily
Namespace Version
20181015
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/3074b85b858455d8eeb76cfcdef685ced19bbe11/external/hgnc.genefamily-names.belns

Appears in Networks 1

Molecular chaperones and proteostasis regulation during redox imbalance v1.0.0

In-Edges 3

bp(GO:"post-translational protein modification") regulates p(HGNCGENEFAMILY:"Small heat shock proteins") View Subject | View Object

sHSPs are tightly regulated by EPMs (e.g. phosphorylation) that enable them to respond upon stress and to perform their chaperone activities [25,26]. PubMed:24563850

Appears in Networks:

bp(GO:"response to stress") increases p(HGNCGENEFAMILY:"Small heat shock proteins") View Subject | View Object

sHSPs are overexpressed upon many different types of stress as they are key components of the PN and PDR. PubMed:24563850

Appears in Networks:

path(MESH:Neoplasms) increases p(HGNCGENEFAMILY:"Small heat shock proteins") View Subject | View Object

Specifically, they have been found overexpressed in many different diseases including various types of cancer where they contribute in reducing proteotoxic stress [7]. PubMed:24563850

Appears in Networks:

Out-Edges 1

p(HGNCGENEFAMILY:"Small heat shock proteins") decreases path(MESH:"Protein Aggregation, Pathological") View Subject | View Object

These chaperones provide high-affinity binding platforms for unfolded proteins and prevent protein aggregation specifically during stress conditions. PubMed:24563850

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.