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a(HBP:"alpha-synuclein fibrils")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
alpha-synuclein fibrils
Namespace
HBP
Namespace Version
20190126
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/77c0796c3ca82a80cb0eaf1c8380d6ccd7f323af/export/hbp-names.belns

Appears in Networks 1

The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg v1.0.0

In-Edges 3

p(HGNC:SNCA, var("p.Ala30Pro")) increases a(HBP:"alpha-synuclein fibrils") View Subject | View Object

The mutant proteins have a higher tendency to generate protofibrils PubMed:14556719

Appears in Networks:

bp(HBP:"Alpha-synuclein Oligomerization") increases a(HBP:"alpha-synuclein fibrils") View Subject | View Object

Wild-type alphaSYN is monomeric, but at high concentration, it oligomerizes to beta-pleated sheets known as protofibrils PubMed:14556719

Appears in Networks:

p(HGNC:SNCA, var("p.Ala53Thr")) increases a(HBP:"alpha-synuclein fibrils") View Subject | View Object

The mutant proteins have a higher tendency to generate protofibrils PubMed:14556719

Appears in Networks:

Out-Edges 1

a(HBP:"alpha-synuclein fibrils") increases a(HBP:"alpha-synuclein aggregates") View Subject | View Object

The protofibrils can further aggregate and precipitate as amyloid fibrils that are present in Lewy bodies, the hallmark of sporadic, late-onset PD PubMed:14556719

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.