1. Catalog
  2. Nodes
  3. p(HGNC:OPTN)

p(HGNC:OPTN)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
OPTN
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing v1.0.0

In-Edges 1

path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:OPTN) View Subject | View Object

ALS shares many causal genes with FTD, including SQSTM1, CHMP2B, TBK1 (which encodes tank-binding kinase 1), OPTN (which encodes optineurin) and other genes associated with deficits in ALN and mitophagy. PubMed:30116051

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons
MeSH
Amyotrophic Lateral Sclerosis

Out-Edges 2

p(HGNC:OPTN) hasVariant p(HGNC:OPTN, var("?")) View Subject | View Object

Appears in Networks:

p(HGNC:OPTN) association path(MESH:"Amyotrophic Lateral Sclerosis") View Subject | View Object

ALS shares many causal genes with FTD, including SQSTM1, CHMP2B, TBK1 (which encodes tank-binding kinase 1), OPTN (which encodes optineurin) and other genes associated with deficits in ALN and mitophagy. PubMed:30116051

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons
MeSH
Amyotrophic Lateral Sclerosis

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.