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complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2))

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Components

Appears in Networks 1

TAU and Interaction Partners v1.2.5

TAU Interactions Section of NESTOR

In-Edges 3

p(HGNC:STUB1) isA complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2)) View Subject | View Object

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p(HGNC:MAPT, pmod(Ph)) isA complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2)) View Subject | View Object

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p(HGNC:UBE2D2) isA complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2)) View Subject | View Object

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Out-Edges 4

complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2)) hasComponent p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

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complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2)) hasComponent p(HGNC:STUB1) View Subject | View Object

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complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2)) hasComponent p(HGNC:UBE2D2) View Subject | View Object

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complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2)) directlyIncreases p(HGNC:MAPT, pmod(Ub)) View Subject | View Object

These data suggest a model by which phosphorylated tau is bound to a chaperone and the complex is recognized by the E3 Ub ligase CHIP. We further examined whether recombinant GST-CHIP ubiquitinates phosphorylated tau in vitro in the presence of UbcH5B and Hsc70. Ubiquitination of phosphorylated tau was detected as high molecular weight bands by immunoblotting with 5E2 in the presence of UbcH5B and Hsc70 (Fig. 2e). PubMed:14612456

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.