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bp(GO:"intracellular signal transduction")

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Entity

Name
intracellular signal transduction
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 3

Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment v1.0.1

Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage v1.0.0

Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage from Shafiei et al., 2017

Alzheimer’s disease and the autophagic-lysosomal system v1.0.0

In-Edges 5

a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"intracellular signal transduction") View Subject | View Object

This enhancement of synaptic plasticity and the activation of intracellular pathways are mediated by the activation of alpha7 nAChRs (Dineley et al., 2001; Parri et al., 2011; Plant et al., 2003; Puzzo et al., 2008) PubMed:25514383

Appears in Networks:

complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) increases bp(GO:"intracellular signal transduction") View Subject | View Object

However, it is clear that nAChR-Aß interaction initiates intracellular signalling implicating a set of transduction cascades PubMed:25514383

Appears in Networks:

complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN), p(HGNC:FLNA)) increases bp(GO:"intracellular signal transduction") View Subject | View Object

The intracellular signalling initiated by the binding of Abeta to nAChR at the cell surface requires the recruitment of Filamin A (FLNA), a scaffold protein that is known to crosslink actin, and in addition could also have a function in certain intracellular pathways (Stossel et al., 2001) PubMed:25514383

Appears in Networks:

p(HGNC:MAPT) association bp(GO:"intracellular signal transduction") View Subject | View Object

This hints that tau plays a role in monitoring intracellular signaling pathways (Pooler and Hanger, 2010) PubMed:28420982

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Hippocampus

a(CHEBI:lipid) regulates bp(GO:"intracellular signal transduction") View Subject | View Object

In addition to their structural role in membranes, lipids are essential in the maintenance of cellular energy homeostasis as well as regulation of intracellular signaling pathways PubMed:29758300

Appears in Networks:

Out-Edges 1

bp(GO:"intracellular signal transduction") association p(HGNC:MAPT) View Subject | View Object

This hints that tau plays a role in monitoring intracellular signaling pathways (Pooler and Hanger, 2010) PubMed:28420982

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Hippocampus

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.